爪蟾蝌蚪胚胎发育毒性实验Tadpole embryonic developmental toxicity testing

以非洲爪蟾胚胎 / 蝌蚪为模型，评价环境因子与化合物对早期发育的影响，开展致畸、致死与发育异常的系统观察（FETAX 思路），适用于环境毒理与药物安全评价。Using Xenopus embryos/tadpoles to assess effects of environmental factors and compounds on early development — teratogenicity, lethality and abnormalities (FETAX-style).

检测能力Capabilities

FETAX：爪蟾胚胎致畸与致死测试FETAX: frog embryo teratogenesis assay
发育终点：存活率、畸形率、体长、心率、行为Endpoints: survival, malformation, length, heart rate, behavior
神经 / 心脏毒性：神经发育与心脏功能评价Neuro/cardiotoxicity: neural & cardiac assessment
分子毒理：转录组、信号通路（如 Notch）分析Molecular: transcriptomics & pathway (e.g. Notch) analysis
受试物：农药、双酚类、内分泌干扰物、纳米材料、电离辐射等Test items: pesticides, bisphenols, EDCs, nanomaterials, ionizing radiation

代表性成果Selected publications

客户使用本服务发表的论文（节选）Client papers using this service

完整名单见客户 SCI 论文精选。Full list: client SCI papers.

Environmental Research2024

Ionizing radiation induces neurotoxicity in Xenopus laevis embryos through neuroactive ligand-receptor interaction pathway

Hou et al. · Environ Res 256:119237 · 电离辐射神经毒性Radiation neurotoxicity

DOI

Environmental Pollution2024

Mitochondrial dynamics disruption: unraveling dinotefuran's impact on cardiotoxicity

Zhu et al. · Environ Pollut 343:123238 · 呋虫胺心脏毒性Dinotefuran cardiotoxicity

DOI

J Hazardous Materials2021

The combined adverse effects of cis-bifenthrin and graphene oxide on lipid homeostasis in Xenopus laevis

Li et al. · J Hazard Mater 407:124876 · 联苯菊酯 + 氧化石墨烯cis-Bifenthrin + graphene oxide

DOI

Sci Total Environ2020

Transcriptional changes caused by estrogenic endocrine disrupting chemicals in gonad-mesonephros complexes of genetic male Xenopus laevis: multiple biomarkers for early detection of testis differentiation disruption

Shen et al. · Sci Total Environ 726:138522 · 雌激素内分泌干扰物Estrogenic EDCs

DOI

Aquatic Toxicology2020

Transcriptomic analysis identifies early cellular and molecular events by which estrogen disrupts testis differentiation and causes feminization in Xenopus laevis

Li et al. · Aquat Toxicol 226:105557 · 雌激素致雄性雌化Estrogen-induced feminization

DOI

Environmental Pollution2020

Effects of bisphenol A and its alternative bisphenol F on Notch signaling and intestinal development: a novel signaling by which bisphenols disrupt vertebrate development

Zhu et al. · Environ Pollut 263(Pt B):114443 · 双酚 A/F 与 NotchBisphenol A/F & Notch

DOI

Toxicology2020

d-Glucuronolactone attenuates para-xylene-induced defects in neuronal development and plasticity in Xenopus tectum in vivo

Liao et al. · Toxicology 430:152341 · 对二甲苯神经发育缺陷para-Xylene neurodevelopmental defects

DOI

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