爪蟾相关研究成果与发育生物学进展。Xenopus research outcomes and developmental biology.
23 篇代表性论文 + 136+ 家客户名单，覆盖离子通道、发育与毒理。23 papers + 136+ clients across channels, development and toxicology.
受精卵 → 卵裂 → 囊胚 → 原肠胚 → 神经胚 → 蝌蚪的关键时期。Egg → cleavage → blastula → gastrula → neurula → tadpole.
卵母细胞表达系统、显微注射、核移植、卵提取物、染色质研究与 Xenbase 数据库。Oocyte expression, microinjection, nuclear transplantation, egg extracts, chromatin and Xenbase.
视觉剥夺减少 SOX2⁺ 神经干细胞，Wnt/β-catenin–SOX2 轴调控经验依赖性细胞稳态。Int J Mol Sci 2023。Visual deprivation reduces SOX2⁺ NSPCs; Wnt/β-catenin–SOX2 axis mediates experience-dependent homeostasis. Int J Mol Sci 2023.
约 1700 万年前两个祖先物种杂交形成异源四倍体基因组，含约 50000 个基因。Nature 2016。Allotetraploid genome formed ~17 Mya by hybridization of two extinct ancestral species; ~50,000 genes. Nature 2016.
Amphibase 项目整合 22 个两栖动物物种转录组数据，克服多倍体基因组注释的技术挑战。Amphibase integrates transcriptome data from 22 amphibian species, addressing polyploid genome annotation challenges.
BONCAT+MudPIT 体内蛋白质组学发现 CPEB 急性合成是爪蟾蝌蚪视觉学习的必要条件。Cell Rep 2014。BONCAT+MudPIT in-vivo proteomics identifies acute CPEB synthesis as essential for visual learning. Cell Rep 2014.
过表达 Kv1.1 降低放电证明相对活动水平在竞争中具有指令性作用，驱动感受野精细化。J Neurosci 2012。Kv1.1 overexpression shows relative firing rate is instructive for competitive refinement of receptive fields. J Neurosci 2012.
双光子钙成像揭示爪蟾视顶盖 100+ 神经元在视觉训练后发生功能性空间集群重组。PLoS Biol 2012。Two-photon imaging reveals functional cluster reorganization of 100+ tectal neurons after visual training. PLoS Biol 2012.
GABAA 受体敲低和地西泮的双向操控均损伤视觉回避行为，证实 E/I 平衡的必要性。J Neurophysiol 2011。Bidirectional E/I manipulation (GABAA knockdown or diazepam) both impair visual avoidance, confirming E/I balance requirement. J Neurophysiol 2011.
从 Hogben 妊娠试验（1930s）到 Gurdon 核移植（1962）与 MPF 发现（1971），爪蟾的辉煌历程。From Hogben's pregnancy test (1930s) to Gurdon's nuclear transplantation (1962) and MPF discovery (1971).
形态特征、习性、激素诱导繁殖、水族箱饲养要点与入侵物种警示。经典科普文章（1991）。Morphology, behavior, HCG-induced spawning, husbandry tips and invasive species warning. Classic popular article (1991).